Four people, including two children, were injured in a collision Tuesday evening in Granby, about an hour east of Montreal.
A semi-trailer truck, a cube van and a car collided on Simonds Street South.
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Two children, a 12-year-old boy and a nine-year-old girl, were critically injured in the crash.
The car they were in was heavily damaged. Officials say they are fighting for their lives in a Sherbrooke hospital.
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Another child, riding in the cab of the truck, was also injured.
Granby police and collision specialists with Quebec provincial police are investigating the incident.