The shuffle is expected to be a small one, affecting as few cabinet ministers as possible just months ahead of the fall federal election.
Insiders confirm that Indigenous Services Minister Jane Philpott will take over for Brison, and Veterans Affairs Minister Seamus O’Regan is also on the move.
He has cancelled an event that was set to take place today in his home province of Newfoundland and Labrador.
WATCH: Unpacking the politics of a cabinet shuffle
The prime minister also must elevate a legislator from Nova Scotia to cabinet to make up for the void Brison leaves.
Political observers have speculated that person will likely be either Sean Fraser or Bernadette Jordan – possibly taking over for O’Regan at Veterans Affairs.