Austin Shanks led Rochester’s offence with five goals, including an empty-netter, and an assist.
Rush forward Robert Church was still hot after a sock trick last week, scoring four goals and adding two assists on Saturday.
The Knighthawks were two-for-four on the power play and netted a short-hander. The Rush scored four power-play goals on eight attempts.
Goaltender Evan Kirk stopped 40 shots in front of a home crowd of 14,811 fans at SaskTel Centre. Matt Vinc made 43 saves for the Knighthawks.
Rochester (7-7) beat Saskatchewan 16-11 in their only other meeting this NLL season on Feb. 17 in New York.
The Rush (11-3) play the Colorado Mammoth (9-4) next in Saskatoon on April 7.