Saturday Night Live’s cold open featured Kate McKinnon as Dr. Anthony Fauci and Heidi Gardner as Dr. Deborah Birx as they discussed the rollout of the COVID-19 vaccine on CNN’s Situation Room with Wolf Blitzer, played by Beck Bennett. Asked by Blitzer on how the low temperature for the vaccine is kept, Birx replies that the vaccine comes in “Coors Light cold-activated cans so if the mountain is blue, you know the vaccine is effective.”