U.S. President Donald Trump on Thursday signed an order recommending the loosening of federal regulations on marijuana, a move that could further reverse decades of tough-on-weed policy. Such a decision would represent one of the most significant federal changes to marijuana policy in decades. It could reshape the cannabis industry, ease criminal penalties, unlock billions in research funding and lead to the opening of doors long closed to banks and investors. Marijuana will remain illegal federally and subject to a patchwork of local laws across the country.