RCMP said emergency services rushed to the scene of the crash, which happened near Purden Ski Hill at 7:45 a.m.
B.C. Emergency Health Services confirmed to Global News that six ambulances and a supervisor responded to the crash. Four people were transported to the hospital.
The helicopter has been identified as a Bell 206L helicopter.
Police said it was privately owned and had been chartered to do some flights in the area.
“We are asking that anyone driving past that area today — remember to give emergency crews plenty of room to work if they are on the highway, by slowing down and moving over and to obey flagger signals,” Cpl. Jennifer Cooper, media relations officer for the Prince George RCMP, said in a statement.
The Transportation Safety Board confirmed a team of investigators has been deployed.