RCMP shared on Thursday that members of the Kindersley and Eston fire departments were called to the incident at approximately 2:30 a.m.
The house fire occurred on the 100 block of Second Avenue Southwest in Madison, Sask., about 40 kilometres south of Kindersley.
Police say the house was fully involved and completely destroyed the residence.
Firefighters later located a deceased person inside the burned ruins of the home.
While Kindersley RCMP members are working with the coroner to determine the person’s identity, a preliminary investigation has determined it may be a man who lived in the home who has not yet been located by police.
Saskatchewan Public Safety Agency fire investigators and Kindersley RCMP continue to investigate the incident.