The Saskatoon Fire Department said it received a 911 call just before 6 p.m. Sunday reporting flames coming from the home in the 1500 block of Rayner Avenue.
Firefighters said they arrived to find the mobile home engulfed in flames and took defensive actions to protect adjacent structures.
The fire department said no one was home at the time.
There are no reports of injuries.
Damage is estimated at $75,000, according to fire investigators.