Edmonton police shut down all lanes of Queen Elizabeth Park Road Sunday morning, after a five-vehicle collision around 11 a.m.
The one-way road connects drivers with the Walterdale Bridge via Saskatchewan Drive.
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There were no injuries to any drivers or passengers involved in the collision, police said.
Motorists were asked to avoid the area and use alternate routes to cross the river.
The road was reopened to traffic just before 3 p.m.
Police continue to investigate.