At approximately 7:45 a.m. on Friday, Bonnyville RCMP were called to a fatal three-vehicle collision on Highway 28 near Township Road 604, southwest of Bonnyville.
Investigators believe an SUV was travelling east on Highway 28 while a car was travelling west when the two collided. A second car travelling west then hit the two vehicles, police said.
The 38-year-old woman driving the SUV was pronounced dead at the scene. The Elk Point woman was alone in the vehicle.
The lone woman driving the first car suffered serious, life-threatening injuries and was taken to hospital before being airlifted via STARS air ambulance to Edmonton.
The man driving the second car was taken to hospital with serious but non-life threatening injuries. He was alone in the vehicle.
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Traffic on Highway 28 was diverted for several hours.
Icy road conditions were reported at the time of the collision, police said.