Police said they seized a quantity of cocaine along with psilocybin during a search of a home in Wynyard, Sask.
Members of Wynyard RCMP, along with officers from other detachments, searched the 2nd Street East home on Friday afternoon.
Police said they also found evidence associated with cocaine trafficking.
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Donald Boucher and Ashley Bouchard are charged with trafficking cocaine, possession of psilocybin and possession of the proceeds of crime.
They will appear Monday morning in Yorkton provincial court.