Emergency crews were called to the scene of a serious crash on Edmonton Trail and Country Centre in Airdrie at 1:15 p.m. on Sunday.
RCMP said it appeared that there was a head on collision and four vehicles were involved.
Three people were taken to hospital in serious non life-threatening condition, according to officials.
Police said the road is was blocked by debris in both directions and a collision analyst was called to the scene.
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RCMP asked motorists are asked to avoid the area while they investigate the cause of the collision.
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