The United States officially served notice Thursday of its intention to renegotiate the agreement, triggering a 90-day consultation window before starting talks late this summer with Canada and Mexico.
Wynne notes that Ontario is the main customer of 20 U.S. states and the second-largest of eight more.
She says nearly nine million U.S. jobs depend on trade and investment with Canada.
The premier says the government is working in Washington and in state capitals across the U.S. to address issues that could affect Ontario-U.S. trade and ensure the province’s interests are represented.
Wynne also says the province has retained legal experts and trade advisers to support ongoing efforts to improve trade with the U.S.