The Saint John Police seized $188,000 worth of drugs as part of what they said is an ongoing investigation into drug trafficking.
Police also seized two firearms and an undisclosed amount of ammunition.
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Police say search warrants were executed on Durham Street, Douglas Avenue and Millidge Avenue, on Tuesday. A vehicle was also searched.
A 49-year-old man, a 54-year-old man and a 49 year old woman have been charged with possession of drugs for the purpose of trafficking as well as possession of firearms.
More arrests are expected.