Driver inexperience was a factor in a crash that closed both southbound lanes and a northbound lane of Circle Drive at College Drive.
Saskatoon police said the two vehicle crash happened just before noon local time when a northbound vehicle crossed the median and struck a southbound vehicle.
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Two people were taken to hospital.
The driver of the southbound car, a 26-year-old man, was taken to hospital with serious, but non-life threatening injuries.
The driver of the northbound vehicle, a 21-year-old woman, was not injured. She was taken to hospital as a precaution.
She has been charged with driving without due care and attention.
Police said driver inexperience was a factor in the crash.
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Traffic had to be diverted from the area for several hours to allow for the protection of investigators and the collection of evidence.
All restrictions have now been lifted.