OPP say the eastbound Highway 403 is closed at Garden Avenue near Brantford where there have been multiple crashes due to white-out weather conditions.
Police say there is a reported seven-vehicle crash, a three-vehicle crash and four transport trucks jackknifed.
Officers say injuries have been reported and they have confirmed at least one person from Brantford in their thirties was transferred to hospital.
The westbound lanes will be closing periodically to remove the vehicles involved in the incident, police said.
Officials will remain on scene as the investigation gets underway.