Guelph police said one man is in a Hamilton trauma centre after being involved in a collision with an SUV on Tuesday.
Police say emergency crews arrived on site just after 11 p.m. following a crash between a motorcycle and an SUV.
The driver of the motorcycle, a 51-year-old Cambridge man, suffered serious injuries and was reportedly airlifted to Hamilton for treatment.
The roads were closed for more than four hours as police investigated.
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Police say the investigation remains ongoing and there is no word on any charges at this time.
Anyone with further information on this incident is asked to come forward.