Police say emergency crews responded around 11:50 p.m. to a single-vehicle collision on Golf Course Road west of Lucknow Line.
A heavily damaged vehicle left the road and ended up in a field, OPP say.
Police say all five people inside the car were rushed to hospital.
An 18-year-old died while four people suffered non-life-threatening injuries.
The deceased has been identified as Euan Muir of Goderich.
Golf Course Road was closed between Lucknow Line and Council Line but has since reopened.
Anyone with information about the crash is asked to contact Huron OPP at 1-888-310-1122 or (519) 482-1677.