The Canadian Academy of Recording Arts and Sciences and CBC say the band will be playing from its upcoming album, We, which is set for release on May 6.
It will be the group’s first time back on the Juno stage since its performance at the 2018 awards.
This year will also mark the first in-person presentation of the awards show since 2019.
The event is set to take place at Toronto’s Budweiser Stage on May 15 and will be broadcast across Canada and online by CBC.
Arcade Fire, co-founded by frontman Win Butler two decades ago, has received multiple awards for its albums, including the 2011 Grammy for album of the year.
On the weekend, Butler’s brother and bandmate Will Butler announced he left Arcade Fire at the end of last year, saying both he and the group have changed over time.
But he stressed the other members are still his “friends and family.”