Sargent Avenue was closed Wednesday morning after police moved in to investigate an assault.
Winnipeg police closed the busy street between Toronto and Beverley Streets at 1:15 a.m. and it was still closed at 7:25 a.m.
Police said the early-morning incident took place in the 700 block of Sargent, and a man was taken to hospital, where he remains in critical condition.
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Anyone with information about the stabbing is asked to call police at 204-986-6219, or Crime Stoppers at 204-786-TIPS (8477).