Takei is best known for his role as Hikaru Sulu in the original Star Trek television series – a role he reprised in six Star Trek films.
Calgary Expo says the star will make a two-day appearance at the 2020 event, visiting on both Saturday, April 25 and Sunday, April 26.
Takei will take part in a photo op and autograph signing sessions, and will take the stage during a panel.
“We’re thrilled that George Takei will be celebrating our 15th anniversary,” spokesperson Kandrix Foong said in a news release.
“George is not only an iconic actor but an extraordinary advocate for causes he believes in,” Foong added.
“You don’t need to be a Trek fan to appreciate his legacy or enjoy his incredible storytelling ability – we can’t wait until April.”
Previously announced guests set to appear at the 2020 Calgary Expo include Lord of the Rings’ Elijah Wood, Sean Astin, Billy Boyd and Dominic Monaghan – as well as actors Brendan Fraser and Giancarlo Esposito.
Tickets for the event, which runs from April 23-26, are available online at CalgaryExpo.com.