A snow squall watch is in effect for the Barrie, Orillia, Midland and Collingwood areas.
Environment Canada said snow squalls are expected to hit the region Wednesday afternoon and evening.
The weather agency says lake effect snow will develop east of Lake Huron and Georgian Bay on Wednesday morning as a Colorado low departs the region.
Officials say lake effect snow will intensify Wednesday afternoon and will persist into the evening.
Environment Canada says strong, westerly wind gusts up to 60 km/h are also expected to develop Wednesday morning.
Officials say blowing snow may cause visibility to be reduced, making travel hazardous.
According to Environment Canada, some locations close to Georgian Bay may receive 15 centimetres of snow.
School buses in Elmvale, Midland, Penetanguishene and Orillia were cancelled on Wednesday due to the weather.