Environment Canada issued a special weather statement on Sunday morning for London, Parkhill, Strathroy and Komoka as well as eastern and western Middlesex County.
A low-pressure system from Texas will bring snow into Southern Ontario beginning Sunday afternoon.
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Snowfalls of 5 to 10 cm are expected, and the limited visibility will likely make travelling difficult.
Heavier snowfalls are expected for the Greater Toronto Area, where a snowfall warning is in effect.
Environment Canada advises travellers to adjust their plans if possible.