A 21-year-old Toronto man has been charged with manslaughter in connection with the disappearance of a missing Markham woman who is presumed dead, after a Canada-wide search warrant was issued by police last month.

Police have issued an arrest warrant for a 21-year-old Toronto man after investigators say a missing Markham woman is now presumed dead.

Homicide detectives have taken over an investigation into the "suspicious" disappearance of a 36-year-old Markham woman last month and are seeking help from the public identifying a possible witness.