Highway 2 east of Slave Lake is shut down after two semis collided early Thursday morning.
Cpl. Curtis Peters with Alberta RCMP said the incident 40 kilometres east of town happened around 2 a.m.
Peters said one semi was having mechanical failure and looking for a place to pull over when it was rear-ended by a second semi, which then caught fire.
The driver of the second semi was ejected and was taken to hospital for serious but non-life-threatening injuries, Peters said.
The driver of the first semi was uninjured and it is not clear if he was taken to hospital as a precaution.
Neither vehicle was transporting dangerous goods.
There is no word on the ages of the drivers or where they are from.
Peters said clean-up crews are in the process of clearing the trucks and debris from the road and the highway is expected to re-open sometime Thursday morning.
There is no word on whether any charges will be laid.