RCMP were called to a single vehicle rollover at the junction of Highway 165 west of Hall Lake at approximately 2:50 a.m. Saturday.
Mounties say alcohol and wet weather may be factors.
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A 30-year-old man and 27-year-old woman, both residents of La Ronge were taken to La Ronge Hospital by ambulance.
The man was then air lifted to a Saskatoon hospital with life-threatening injuries.
No names have been released at this time.
RCMP continue to investigate.
Hall Lake is approximately 335 km north of Saskatoon.
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