Two people were taken to a trauma centre after a five-vehicle crash on the 401 eastbound express, east of Warden Avenue in Scarborough.
The crash happened shortly after noon on Saturday.
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A man and woman, both in their 30s and riding in the same vehicle together, were taken to a trauma centre with serious injuries.
According to paramedics, four others also sustained minor injuries, and were taken to a local hospital.
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